ea0035p1126 | Thyroid Cancer | ECE2014
Colombo Carla
, Muzza Marina
, Rossi Stefania
, Cirello Valentina
, Perrino Michela
, Tosi Delfina
, Vigo Beatrice
, Leo Simone De
, Bulfamante Gaetano
, Magnani Elisa
, Pignatti Elisa
, Simoni Manuela
, Vicentini Leonardo
, Fugazzola Laura
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends and plays a role in cellular senescence, being repressed in postnatal somatic cells. Mutations C228T and C250T of the telomerase reverse transcriptase (TERT) were recently reported in human cancers. In thyroid cancer, TERT mutations are more frequent in aggressive histotypes, but very few data are available about the potential correlations with clinical features in papillary and follicular thyroid cancer...